TABLE 3.
Comparison of early‐onset T2DM patients with different insulin resistance degree.
| Variables | Mild IR group | Moderate IR group | Severe IR group | P value |
|---|---|---|---|---|
| Gender (%) | .793 | |||
| Male | 258 (76.8) | 130 (76.5) | 80 (80.0) | |
| Female | 78 (23.2) | 40 (23.5) | 20 (20.0) | |
| Onset age (year) | 31.36 ± 0.32 | 31.54 ± 0.45 | 31.39 ± 0.58 | .884 |
| SBP (mm Hg) | 124.36 ± 0.83 | 129.70 ± 1.26 | 131.58 ± 1.68 | <.0001 |
| DBP (mm Hg) | 79.43 ± 0.63 | 84.03 ± 1.02 | 84.62 ± 1.21 | <.0001 |
| BMI (kg/m2) | 26.30 ± 0.25 | 29.18 ± 0.42 | 30.94 ± 0.56 | <.0001 |
| Weight (kg) | 77.16 ± 0.87 | 86.21 ± 1.42 | 91.47 ± 2.00 | <.0001 |
| Height (cm) | 170.95 ± 0.46 | 171.58 ± 0.62 | 171.36 ± 0.72 | .627 |
| Smoking status (%) | .335 | |||
| No | 166 (49.4) | 95 (55.9) | 55 (55.0) | |
| Yes | 170 (50.6) | 75 (44.1) | 45 (45.0) | |
| Drink (%) | .466 | |||
| No | 198 (58.9) | 104 (61.2) | 54 (54.0) | |
| Yes | 138 (41.1) | 66 (38.8) | 46 (46.0) | |
| DM family history (%) | .093 | |||
| No | 166 (49.4) | 72 (42.4) | 38 (38.0) | |
| Yes | 170 (51.7) | 98 (57.6) | 62 (62.0) | |
| FBG (mmol/L) | 9.24 ± 0.22 | 10.41 ± 0.33 | 10.81 ± 0.49 | <.0001 |
| HbA1c (%) | 9.69 ± 0.16 | 9.65 ± 0.17 | 9.74 ± 0.23 | .996 |
| Fatty liver (%) | <.0001 | |||
| No | 126 (37.5) | 19 (11.2) | 11 (11.0) | |
| Yes | 210 (62.5) | 151 (88.8) | 89 (89.0) | |
| Diabetic retinopathy (%) | .790 | |||
| No | 317 (94.3) | 160 (94.1) | 96 (96.0) | |
| Yes | 19 (5.7) | 10 (5.9) | 4 (4.0) | |
| DPN (%) | .993 | |||
| No | 319 (94.9) | 161 (94.7) | 94 (94.0) | |
| Yes | 17 (5.1) | 9 (5.3) | 6 (6.0) | |
| Macrovascular diseases (%) | .563 | |||
| No | 267 (79.5) | 128 (75.3) | 78 (78.0) | |
| Yes | 69 (20.5) | 42 (24.7) | 22 (22.0) | |
| Diabetic nephropathy (%) | .016 | |||
| No | 321 (95.5) | 155 (91.2) | 88 (88.9) | |
| Yes | 15 (4.5) | 15 (8.8) | 12 (12.1) | |
| WHR | 0.95 ± 0.004 | 0.98 ± 0.005 | 0.99 ± 0.006 | <.0001 |
| eGFR (ml/min/1.73 m2) | 122.98 ± 1.80 | 118.17 ± 1.99 | 115.26 ± 2.58 | .046 |
| UA (umol/L) | 348.26 ± 11.34 | 375.26 ± 8.84 | 437.30 ± 32.54 | .001 |
| TG (mmol/L) | 2.56 ± 0.18 | 3.56 ± 0.25 | 4.17 ± 0.11 | <.0001 |
| TC (mmol/L) | 4.76 ± 0.11 | 5.01 ± 0.11 | 5.20 ± 0.22 | .063 |
| HDL‐C (mmol/L) | 0.97 ± 0.02 | 0.90 ± 0.02 | 0.85 ± 0.05 | .02 |
| LDL‐C (mmol/L) | 2.88 ± 0.05 | 2.97 ± 0.08 | 3.00 ± 0.11 | .496 |
| ALT (U/L) | 24.30 (14.45,41.10) | 37.50 (23.00,61.20) | 54.25 (28.38,95.70) | <.0001 |
| AST (U/L) | 16.80 (12.75,25.95) | 22.20 (16.00,32.80) | 28.85 (18.45,48.70) | <.0001 |
| GGT (U/L) | 44.34 ± 4.30 | 52.99 ± 3.56 | 72.22 ± 6.82 | .001 |
| WBC (109/L) | 6.81 ± 0.10 | 7.23 ± 0.13 | 7.45 ± 0.22 | .003 |
| Neutrophil (%) | 0.54 ± 0.005 | 0.55 ± 0.007 | 0.54 ± 0.009 | .901 |
| NLR | 1.67 ± 0.05 | 1.71 ± 0.07 | 1.69 ± 0.09 | .970 |
| Lymphocyte (%) | 0.36 ± 0.005 | 0.36 ± 0.006 | 0.36 ± 0.009 | .765 |
| Monocyte (%) | 0.06 ± 0.001 | 0.07 ± 0.001 | 0.07 ± 0.002 | .920 |
| MLR | 0.19 ± 0.005 | 0.19 ± 0.006 | 0.19 ± 0.009 | .983 |
| Platelet (109/L) | 248.38 ± 3.8 | 247.47 ± 5.18 | 259.45 ± 7.61 | .346 |
| PHR | 280.53 ± 5.98 | 294.36 ± 9.05 | 322.50 ± 13.08 | .005 |
| RC (mmol/L) | 0.52 (0.33,0.84) | 0.78 (0.48,1.23) | 0.78 (0.52,1.67) | <.0001 |
| LDL‐C/HDL‐C | 3.23 ± 0.07 | 3.46 ± 0.09 | 3.59 ± 0.13 | .02 |
| TG/HDL‐C | 1.93 (1.13,3.02) | 2.81 (1.82,4.87) | 2.84 (1.99,7.04) | <.0001 |
| TC/HDL‐C | 5.36 ± 0.15 | 6.00 ± 0.19 | 6.59 ± 0.36 | <.0001 |
| UACR | 8.80 (5.30,15.00) | 9.00 (5.00,18.30) | 11.00 (6.33,25.75) | .075 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartic transaminase; BMI, body mass index; DBP, diastolic blood pressure; DM, diabetes mellitus; DPN, diabetic peripheral neuropathy; eGFR, estimated glomerular filtration rate; FBG, fasting blood‐glucose; GGT, gamma‐glutamyl transpeptidase; HbA1c, glycosylated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; IR, insulin resistance; LDL‐C, low‐density lipoprotein cholesterol; LDL‐C/HDL‐C, LDL‐C/HDL‐C ratio; MLR, monocyte to lymphocyte ratio; NLR, neutrophil to lymphocyte ratio; PHR, platelet/HDL‐C ratio; RC, remnant cholesterol; SBP, systolic blood pressure; T2DM, type 2 diabetes mellitus; TC, total cholesterol; TC/HDL‐C, TC/HDL‐C ratio; TG, triglyceride; TG/HDL‐C, TG/HDL‐C ratio; UA, uric acid; UACR, urinary albumin‐to‐creatinine ratio; WBC, white blood cell; WHR, waist‐to‐hip ratio.