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Tumour-derived exosomes are generated through ESE, LSE, and ILVs in MVBs. After being secreted, exosomes can participate in the pro- and anti-angiogenesis of cancer by the cargos. ESE early-sorting endosome, LSE late-sorting endosome, ILVs intraluminal vesicles, MVBs multivesicular bodies, HUVEC human umbilical vein endothelial cell
