Table 1.
Exosomes in angiogenesis of digestive system tumours
| Cancer | Function | Type | Contents | Reference |
|---|---|---|---|---|
| Oesophageal cancer | Proangiogenesis | lncRNA | FAM225A | [88] |
| microRNA | miR-21-5p | [90] | ||
| miR-301a-3p | [91] | |||
| Antiangiogenesis | microRNA | miR-154-5p | [93] | |
| Gastric cancer | Proangiogenesis | protein | YB-1 | [96] |
| protein | GRP78 | [101] | ||
| circular RNA | circSHKBP1 | [95] | ||
| circular RNA | circ29 | [98] | ||
| microRNA | miR-23a | [94] | ||
| microRNA | miR-10a-5p | [99] | ||
| microRNA | miR-519a-3p | [187] | ||
| ncRNA | X26nt | [97] | ||
| Antiangiogenesis | microRNA | miR-6785-5p | [188] | |
| Colorectal cancer | Proangiogenesis | protein | Angiopoietin-like 7(ANGPTL7) | [104] |
| protein | Wnt4 | [106] | ||
| protein | Glucose-regulated protein 78 (GRP78) | [107] | ||
| protein | dipeptidyl peptidase IV (DPP4) | [115] | ||
| protein | growth/differentiation factor 15 (GDF15) | [116] | ||
| circular RNA | circTUBGCP4 | [117] | ||
| circular RNA | circ_0007334 | [114] | ||
| microRNA | miR‑1246 | [105] | ||
| microRNA | miR-25-3p | [108] | ||
| microRNA | miR-1229 | [109] | ||
| microRNA | miR-92a-3p | [110, 111] | ||
| microRNA | miR-183-5p | [112] | ||
| microRNA | miR-21-5p | [113] | ||
| microRNA | miR-135b-5p | [118] | ||
| Antiangiogenesis | circular RNA | circ FNDC3B | [120] | |
| microRNA | miR-126 | [121] | ||
| microRNA | miR-125a-3p | [121] | ||
| microRNA | miR-125a-5p | [121] | ||
| microRNA | miR-34a | [122] | ||
| Hepatic cancer | Proangiogenesi | protein | lysyl oxidase-like 1–4 (LOXL1–4) | [130] |
| protein | Angiopoietin-2 (ANGPT2) | [132] | ||
| protein | RAB13 | [140] | ||
| lncRNA | lncRNA H19 | [123] | ||
| lncRNA | LINC00161 | [133] | ||
| lncRNA | small nucleolar RNA host gene 16 (SNHG16) | [139] | ||
| circular RNA | circRNA-100,338 | [131] | ||
| circular RNA | circCMTM3 | [138] | ||
| microRNA | miR-32-5p | [124] | ||
| microRNA | miR-210 | [125] | ||
| microRNA | miR-155 | [126] | ||
| microRNA | miR-21 | [127] | ||
| microRNA | miR-378b | [136] | ||
| microRNA | miR-1290 | [137] | ||
| Antiangiogenesis | protein | C-Type Lectin Domain Family 3 Member B (CLEC3B) | [141] | |
| microRNA | miR-200b-3p | [142] | ||
| microRNA | miR-3682-3p | [143] | ||
| Pancreatic cance | Proangiogenesis | protein | annexin A1 (ANXA1) | [144] |
| lncRNA | lncRNA SNHG11 | [146] | ||
| lncRNA | lncRNA UCA1 | [148] | ||
| microRNA | miR-27a | [145] | ||
| microRNA | miR-30b-5p | [149] | ||
| microRNA | miR-210 | [150] | ||
| microRNA | miR-501-3p | [152] | ||
| microRNA | miRNAs 155-5p and 221-5p | [153] | ||
| Antiangiogenesis | microRNA | miR-29b | [151] |