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. 2024 Feb 12;15:1280. doi: 10.1038/s41467-024-45520-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Experimental scheme of Hsp90β^fl/fl or Hsp90β^ΔHep mice injected with ADV–NC or ADV-Shh on HFFC diet. b Western blot analysis in the liver tissues of Hsp90β^fl/fl and Hsp90β^ΔHep mice injected with ADV–NC or ADV-Shh on HFFC diet (n = 6 mice per group). c Representative H&E-stained FFPE liver sections and ORO-stained frozen liver sections. Each arrow indicated hepatocyte ballooning. d Serum IL-1β levels of Hsp90β^fl/fl and Hsp90β^ΔHep mice injected with ADV–NC or ADV-Shh on HFFC diet (Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 0.0018, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 0.0010, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.99). e Representative liver sections stained with F4/80. f The expression of inflammatory genes in livers of Hsp90β^fl/fl and Hsp90β^ΔHep mice injected with ADV–NC or ADV-Shh on HFFC diet (for Il-1β, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 3.6E-06, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 6.7E-07, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.96; for Tnf-α, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 0.0022, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 0.023, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.99; for Il-6, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 2.8E-05, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 3.5E-06, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.99). g Representative liver sections stained with Masson or Sirius red. h The expression of fibrogenic genes in livers of Hsp90β^fl/fl and Hsp90β^ΔHep mice injected with ADV–NC or ADV-Shh on HFFC diet (for Col1a1, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 1.6E-05, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 1.3E-04 Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.94; for Col3a1, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 1.8E-05, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 3.1E-04, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.99; for α-Sma, Hsp90β^fl/fl–NC versus Hsp90β^fl/fl–Shh, P = 0.011, Hsp90β^fl/fl-Shh versus Hsp90β^ΔHep-Shh, P = 0.0023, Hsp90β^ΔHep-NC versus Hsp90β^ΔHep-Shh, P = 0.99). Data are presented as mean ± SEM. n = 6 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001, NS no significant difference, one-way ANOVA. Source data are provided in the Source Data file.