Figure 1.

Tumor associated macrophage (TAM) subpopulations with distinct gene signatures in solid tumor tissues. The genes used to recognize TAM population and subpopulations, generally including T cell immune checkpoint ligands on the membrane surface such as PD-L1, PDL2, CD80, and CD86, surface immune suppressive molecules such as CD163, CD68 and MRC1 (CD206) and specific core gene signatures such as FCN1 ⁺, C1Q A/B/C ⁺, SPP1 ⁺ or CCL18 ⁺ in different TAM subpopulations. Gene with red color, a core gene in each distinct TAM subpopulation.