Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 29;14:1264774. doi: 10.3389/fimmu.2023.1264774

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Wang, Zhu, Su, Gao and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Potential functions of FCN1 ⁺, C1Q ⁺, SPP1 ⁺ and CCL18 ⁺ TAM subpopulations in tumor microenvironments. SPP1 ⁺ tumor associated macrophage (TAM) subpopulation exerts multiple roles in tumor development such as tumor metastasis, angiogenesis and tumor stem cell activation; Whereas a main function of C1Q⁺ TAM population is immunosuppression. CCL18 TAM subpopulation has stronger immunosuppressive function. FCN1 ⁺ TAM subpopulation is inflammatory macrophages, which can cause inflammation. Dotted line arrow, predicted TAM subpopulations based on core gene signatures.