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. 2024 Jan 29;18:1310282. doi: 10.3389/fnins.2024.1310282

Table 1.

Comparison of well-known fluorescence intensity spectroscopy systems.

Haj-Hosseini et al. (2010) Stummer et al. (2014) and Stummer (2015) Alston et al. (2019) Dartmouth-Toronto Team (Kim et al., 2010; Valdés et al., 2011b, 2012c)
Excitation source(s) 1 Laser Diode @ 405 nm D-Light System (broadband) 3 LED @ 375 nm, 405 nm, 420 nm LED @ 405 nm
Spectral resolution
  • 3 nm

  • Unknown

  • 4 nm

0.1–10 nm
Spectral bandwidth 240–850 nm Unknown 220–1,100 nm 450–850 nm
Probe geometry Concentric: Concentric: Concentric: Linear:
  • one central excitation fiber

  • nine detection fibers

  • one central excitation fiber

  • six detection fibers

  • one central detection fiber

  • seven excitation fibers

  • array of four optical fibers

Pros
  • Higher sensitivity (large number of photons captured by the detection fibers)

  • Greater uniformity of explored field

  • Multi spectral excitation

  • Higher sensitivity

  • Greater uniformity of explored field

  • Able to quantify fluorescence

Cons
  • Performs only qualitative intensity fluorescence spectroscopy

  • Less signal detected