TABLE 1.
Demographic characteristics of the included patients.
| Variable | Total (n = 98) | Min–Max |
|---|---|---|
| Sex | ||
| Male | 65 (66.3%) | |
| Female | 33 (33.7%) | |
| Age (years) | 63.4 ± 18.0 | 20–92 |
| Weight (kg) | 62.3 ± 12.4 | 38–92.5 |
| BMI (kg/m2) | 22.7 ± 3.72 | 13.9–31.1 |
| Infected site, n (%) | ||
| Intra-abdominal infection | 37 (37.8%) | |
| Pulmonary infection | 31 (31.6%) | |
| Skin and soft tissue infection | 6 (6.12%) | |
| Bloodstream infection | 9 (9.18%) | |
| Trauma | 7 (7.14%) | |
| Others | 22 (22.4%) | |
| Pathogen | ||
| CRAB | 46 (46.9%) | |
| CRKP | 24 (24.5%) | |
| CRPA | 2 (2.04%) | |
| CRE | 1 (1.02%) | |
| MRSA | 1 (1.02%) | |
| ESBL+ | 2 (2.04%) | |
| Other | 25 (25.5%) | |
| undefined | 7 (7.14%) | |
| MIC | ||
| 0.12 mg/L | 5 (5.10%) | |
| 0.25 mg/L | 1 (1.02%) | |
| 0.5 mg/L | 22 (22.4%) | |
| 1 mg/L | 38 (38.8%) | |
| 2 mg/L | 19 (19.4%) | |
| 4 mg/L | 2 (2.04%) | |
| undefined | 11 (11.2%) | |
| Daily dose | ||
| 100 mg/d | 91 (92.9%) | |
| 200 mg/d | 7 (7.14%) | |
| Treatment duration (day) | 12 (8,20) | 4–68 |
| CCr (mL/min) | 77.0 (51.1,142) | 6.40–338 |
| Laboratory data | ||
| BUN (mmol/L) | 10.8 (7.29,17.0) | 1.46–44.8 |
| SCr (μmol/L) | 64.0 (44.0,103) | 17.0–565 |
| TP (g/L) | 51.1 (46.2,56.2) | 7.40–81.2 |
| ALB (g/L) | 27.9 (25.8,30.3) | 17.3–38.3 |
| ALT (U/L) | 19.0 (12.0,34.0) | 2.00–1974 |
| AST (U/L) | 24.0 (18.0,37.0) | 7.00–829 |
| ALP (U/L) | 99.0 (75.0,139) | 31.0–2548 |
| GGT (U/L) | 53.0 (30.0,103) | 8.00–1088 |
| TBIL (μmol/L) | 15.7 (10.0,30.4) | 4.00–144 |
| PT (s) | 16.5 (15.1,17.9) | 12.6–30.5 |
| WBC (109/L) | 8.30 (5.10,12.0) | 0.100–43.4 |
| RBC (1012/L) | 2.53 (2.32,2.88) | 1.62–4.52 |
| PLT (109/L) | 139 (68.0,225) | 1.00–615 |
All covariates data were measured on the day of concentration monitoring. All continuous data are presented as the mean ± standard deviation or median and interquartile range, and categorical data are presented as numbers and percentages.
Abbreviations: BMI, body mass index; CRAB, carbapenem-resistant Acinetobacter baumannii; CRKP, carbapenem-resistant Klebsiella pneumoniae; CRPA, carbapenem-resistant Pseudomonas aeruginosa; CRE, carbapenem-resistant Enterobacteriaceae; MRSA, methicillin-resistant Staphylococcus aureus; ESBL, extended spectrum beta-lactamase; MIC, minimum inhibitory concentration; ECMO, extracorporeal membrane oxygenation; CCr, creatinine clearance; BUN, blood urea nitrogen; SCr, serum creatinine; TP, total protein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; TBIL, total bilirubin; PT, prothrombin time; WBC, white blood cell; RBC, red blood cell; PLT, platelet.