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. 2023 Sep 1;14(1):1–15. doi: 10.1016/j.jpha.2023.08.019

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 6 — Major molecular mechanisms of tumorigenesis and development associated with lipid metabolic networks in esophageal cancer. CPT1: carnitine palmitoyl transferase 1; FAO: fatty acid oxidation; CD36: cluster of differentiation 36; PPARG: peroxisome proliferator-activated receptor gamma; ELF3/KLF5/GATA6: transcription factors; ACLY: ATP-citrate lyase; ACC: acetyl-CoA carboxylase; FASN: fatty acid synthetase; SCD: stearoyl-CoA desaturase; FA: fatty acid; LD: lipid droplet; SREBP1: sterol regulatory element-binding protein 1; EMT: epithelial-mesenchymal transition; FTO: fat-mass and obesity-associated protein; HSD17B11: hydroxysteroid 17-beta dehydrogenase 11; TNFα: tumor necrosis factor α; FOXC2: forkhead box protein C2; FA2H: fatty acid 2-hydroxylase; Cer: ceramide; CYP2C and CYP2J: cytochrome P450 superfamily members; LPCAT1: lysophosphatidylcholine acyltransferase; PI3K: phosphatidylinositol 3-kinases; SP1/SREBF2: transcription factors; SQLE: squalene epoxidase; pEGFR: phosphorylated epidermal growth factor receptor; pSREBP1: phosphorylated sterol regulatory element-binding protein 1.