TABLE 2.
Changes of CRN lesions' MRI features at the different study time points.
| Therapeutic effect | Low‐dose group (35) | High‐dose group (43) | ||||
|---|---|---|---|---|---|---|
| 3 months | 6 months | 3 months | 6 months | P1 | P2 | |
| CRN edema volume on T2FLAIR, ml | 23.4 (6.4–30.4) | 22.6 (7.0–36.2) | 20.1 (4.8–49.1) | 26.5 (5.1–68.2) | 0.655 | 0.404 |
| p for edema volume compared with baseline | <0.001 | <0.001 | <0.001 | <0.001 | — | — |
| % reduction in edema volume compared with baseline | 65.8 (48.5–79.2) | 59.5 (44.9–77.4) | 64.8 (42.5–85.2) | 62.0 (6.7–82.3) | 0.860 | 0.757 |
| CRN‐enhanced volume on T1CE, ml | 2.0 (0.9–3.5) | 2.5 (1.1–4.1) | 2.0 (0.7–5.1) | 2.5 (1.2–6.6) | 0.517 | 0.419 |
| p for enhanced volume compared with baseline | <0.001 | 0.004 | <0.001 | <0.001 | — | — |
| % reduction in enhanced volume compared with baseline | 41.2 (26.3–61.9) | 39.1 (−2.4,54.3) | 51.9 (27.3–66.7) | 31.3 (1.6–60.0) | 0.396 | 0.851 |
| Signal ratio of CRN‐enhanced area on T1CE | 1.3 (1.1–1.4) | 1.3 (1.2–1.6) | 1.3 (1.2–1.6) | 1.5 (1.2–11.9) | 0.154 | 0.091 |
| p for signal ratio compared with baseline | <0.001 | <0.001 | <0.001 | <0.001 | — | — |
| % reduction in signal ratio compared with baseline | 37.4 (31.0–46.5) | 35.4 (22.5–47.4) | 35.1 (25.6–46.5) | 28.2 (8.3–43.9) | 0.271 | 0.083 |
Note: Data are shown as numbers (%) or medians (IQRs). P1, low‐dose group versus high‐dose group at 3 months; P2, low‐dose group versus high‐dose group at 6 months.
Abbreviation: CRN, cerebral radiation necrosis; T2FLAIR, T2‐weighted fluid‐attenuated inversion recovery; T1CE, T1‐weighted gadolinium contrast‐enhanced image.