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. 2023 Dec 2;12(1):22–33. doi: 10.1002/ueg2.12485

TABLE 1.

Publicly available data from microbiota studies of IBD patients.

Study Country UC/CD/HI % Males Age span Status
Papa et al. (2012) 15 USA 43/23/24 48.9 3–24 1
Pérez‐Brocal et al. (2013) 16 Spain 0/11/8 ‐ ‐
Gevers et al. (2014) 17 USA 0/233/71 58.7 Mean: 12.3
Norman et al. (2015) 18 USA, United Kingdom 59/39/55 43.1 Mean: 41.5 4
Pérez‐Brocal et al. (2015) 19 Spain 0/12/12 37.5 18–71
Duranti et al. (2016) 20 Italy 14/0/14 39.3 25–45 2
Jacobs et al. (2016) 21 USA 10/26/54 55.6 Mean: 14.0 3
Tedjo et al. (2016) 22 The Netherlands 0/71/0 46.5 18–70 2
Bajer et al. (2017) 23 Czech Republic 32/0/31 47.6 20–72 2
Ijaz et al. (2017) 24 Scotland 0/19/31 60.0 IQR: 11–50
Jacob et al. (2017) 25 USA 0/20/2 60.0 23–71 2
Iwasawa et al. (2017) 26 Japan 16/0/23 43.6 3–23
Santoru et al. (2017) 27 Italy 82/50/51 54.1 Mean: 45.9 1
Doherty et al. (2018) 28 USA 0/306/0 38.2 Mean: 39.0
Forbes et al. (2018) 29 Canada 19/20/23 38.7 Mean: 43.8
Goyal et al. (2018) 30 USA 12/7/0 57.1 8–21
Kennedy et al. (2018) 31 United Kingdom 0/37/54 47.3 43–65 1
Kump et al. (2018) 32 Austria 27/0/0 63.0 Mean: 41.0 2
Mcdonald et al. (2018) 33 Many 112/82/1770 53.3 0–89
Schäffler et al. (2018) 34 Germany 0/7/10 64.7 Mean: 33.1 2
Shutkever et al. (2018) 35 United Kingdom 120/150/0 44.1 Mean: 50.1 1
Smolinska et al. (2018) 36 The Netherlands 0/68/0 44.0 18–70 2
Zhou et al. (2018) 37 China 51/72/71 56.1 Mean: 33.7 2
Braun et al. (2019) 38 Israel 0/45/22 59.7 Mean: 35.6 3
Cold et al. (2019) 39 Denmark 7/0/0 71.4 27–50 2, 5
Li et al. (2019) 40 China 0/9/9 55.1 Mean: 35.8 2
Presti et al. (2019) 41 Italy 31/7/47 56.5 21–74
Weng et al. (2019) 42 China 107/173/42 65.8 IQR: 21–53 1
Alam et al. (2020) 43 United Kingdom 11/10/9 ‐ ‐ 2, 5
Ambrozkiewicz et al. (2020) 44 Poland 0/15/9 66.7 a 20–65 a 2
Ayelén et al. (2020) 45 Argentina 20/0/0 ‐ ‐
Diederen et al. (2020) 46 The Netherlands 0/27/15 52.0 a IQR: 12–15 a 2, 5
MacHiels et al. (2020) 47 Belgium 0/54/0 47.5 Mean: 51.4 2
Metwaly et al. (2020) 48 Spain 0/15/0 27.6 ‐ 2
Schierová et al. (2020) 49 Czech Republic 16/0/0 50.0 28–66 3, 5
Sokol et al. (2020) 50 France 0/17/0 52.9 IQR: 29–37
Wang et al. (2020) 51 China 58/0/72 51.5 Mean: 43.9 2
Clooney et al. (2021) 52 Canada, Ireland 228/303/161 54.3 Mean: 50.3 1, 5
Cortez et al. (2021) 53 Brazil 12/0/23 68.6 2–21
Dai et al. (2021) 54 China 24/0/14 55.3 Mean: 34.9 2
Frau et al. (2021) 55 United Kingdom 20/23/20 50.8 Mean: 44.8 1
Imai et al. (2021) 56 Japan 42/16/45 59.0 Mean: 29.5 4
Maldonado‐Arriaga et al. (2021) 57 Mexico 18/0/15 57.6 Mean: 36.9 1
Schierova et al. (2021) 58 Czech Republic 10/17/37 34.4 IQR: 26–44
Zakerska‐Banaszak et al. (2021) 59 Poland 10/0/10 45.0 Mean: 46.3 2, 5

Note: A total of 45 studies were eligible for this project. Information on sex and age was collected from each publication for both ulcerative colitis (UC) and Crohn's disease (CD) patients as well as healthy individuals (HI). Status 1 = publicly available data missed individual level information on disease status, age, and sex. Status 2 = publicly available data missed individual level information on age and sex. Status 3 = publicly available data missed individual level information on either age or sex. Status 4 = subject names in publication do not match subject names of sequencing data. Status 5 = Additional individual level data was received from authors. ‐: Not reported in publication.

Abbreviations: CD, Crohn's disease; HI, healthy individuals; IBD, inflammatory bowel diseases; IQR, inter‐quartile range; UC, ulcerative colitis.

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