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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Nat Rev Microbiol. 2023 Aug 30;21(12):818–832. doi: 10.1038/s41579-023-00960-9

Figure 5.

Figure 5.

Mechanisms of acquired resistance of Trichophyton indotineae. T. indotineae is a newly emerging species so our current knowledge of the mechanisms of resistance is limited. Resistance to terbinafine is caused by specific mutations in the target enzyme, squalene epoxidase, which may also lead to azole resistance as it is a component of the ergosterol pathway. Azole resistance has been linked to changes in the target enzyme lanosterol demethylase (CYP51B) either through amino acid mutation, changes in ploidy, or mutations in transcription factors that result in overexpression.