Fig. 8.

A) Cα displacement cross-correlation matrices for the HisF_wt and HisF-Y182A mutant. The molecular dynamics of these proteins were simulated at different temperatures. Blue dots mean positive correlation above 0.2 and red dots indicate negative correlation below −0.2. B) Average number of the positive, negative and total correlations shown in each cross-correlation matrix. Analyses were based on the average of 4 independent molecular dynamic simulations at each temperature. *p < 0.05; ⁺p < 0.1.