. 2023 Dec 11;34(12):2345–2357. doi: 10.1021/acs.bioconjchem.3c00455

Table 3. Qualitative Evaluation of CSP or Effects in ¹H 1D Spectra with Relaxation/Diffusion Filters^a.

cage	polyE₄Y			polyK₄Y			polyE₆K₃Y
	CSP	relaxation	diffusion	CSP	relaxation	diffusion	CSP	relaxation	diffusion
CyLys	+++	+++	+++	nm	nm	nm	++	++	+
CyHis	+	+	–	–	–	–	++	+	++
CyAsp	++	–	–	+	++	++	+	–	–

nm, not measured; −, no changes; and + to +++, low-to-high changes in NMR spectra. (+ to +++) In agreement with established intensity loss levels in the Materials and Methods section and Table 1: diffusion, no binding <25%, weak <50%, medium <80%, and strong >80%; relaxation, no binding <15%, weak <40%, medium <60%, and strong >60%.

Table 3. Qualitative Evaluation of CSP or Effects in 1H 1D Spectra with Relaxation/Diffusion Filtersa.

Table 3. Qualitative Evaluation of CSP or Effects in ¹H 1D Spectra with Relaxation/Diffusion Filters^a.