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. 2024 Jan 31;67(3):1783–1811. doi: 10.1021/acs.jmedchem.3c01276

Table 3. Effect of Complexes on A549 Cancer Cells Viability.

  dark blue light
 green light
 red light
complex IC50 (μM) IC50 (μM) PIa IC50 (μM) PIa IC50 (μM) PIa
1 8.0 ± 1 2.9 ± 0.4 2.8 5.8 ± 0.1 1.4 n.m. n.m.
2 2.2 ± 0.9 0.0069 ± 0.001 323 0.032 ± 0.01 68.7 0.60 ± 0.04 3.7
3 4.9 ± 0.7 1.2 ± 0.1 4.1 2.5 ± 0.3 2.0 n.m. n.m.
4 2.9 ± 1 0.0032 ± 0.002 932 0.010 ± 0.003 294 0.12 ± 0.05 25
5 0.83 ± 0.02 0.39 ± 0.1 2.1 0.52 ± 0.02 1.6 n.m. n.m.
6 2.0 ± 0.1 0.0015 ± 0.0005 1317 0.011 ± 0.004 179 0.032 ± 0.01 63
7 0.77 ± 0.2 0.65 ± 0.2 1.2 0.47 ± 0.04 1.7 n.m. n.m.
8 0.15 ± 0.05 0.00020 ± 0.0001 764 0.0021 ± 0.0004 71 0.030 ± 0.02 5.0
9 8.7 ± 1 5.3± 0.4 1.6 n.m. n.m. n.m. n.m.
10 10 ± 0.3 5.6± 0.4 1.8 n.m. n.m. n.m. n.m.
Imepip 68 ± 2 n.m. n.m. n.m. n.m. n.m. n.m.
Cisplatin 8.9 ± 2 n.m. n.m. n.m. n.m. n.m. n.m.
a

A549 cells were incubated with the compounds for 4 h at 37 °C and then kept in the dark or exposed to blue (460 nm), green (530 nm), and red (655 nm) light for 1 h (24.1 J cm–2). Cell viability was assessed after 48 h of treatment by MTT assays. Data represents mean ± standard deviation (SD) of at least three independent experiments, each performed in triplicate. PI = IC50,dark/IC50,light. n.m.: not measured.