Figure 3.

Crystal structure of SIRT3 in complex with AceCS-2 12-mer peptide. (left) The full SIRT3 structure with its substrate analogue. (right) The most important residues for the binding of the substrate. In particular, residues G295, E296, and L298 of the large domain and residues E323 and E325 of the small domain that form hydrogen bonds are depicted in yellow. F294 and V324 are depicted in cyan. H248 and F180 are depicted in green. V292 is highlighted in red. I291 and I230 are depicted in orange. H bonds are depicted with blue dotted lines (PDB 3GLR).