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Experimental infection of Mongolian gerbils with wild-type and isogenic mutants of H. pylori G1.1
| Bacterial genotype | No. of infected animals/no. challenged at time (wk) postchallenge:
|
Total no. | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 6 | 8 | 12 | 16 | 20 | 24 | 32 | ||
| Wild type | 14/15 | 16/17 | 5/5 | 7/7 | 7/7 | 12/12 | 21/21 | 2/2 | 9/9 | 2/2 | 4/4 | 99/101 |
| cagA | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 5/5 | 5/5 | 25/25 | ||||
| vacA | 2/3 | 3/3 | 3/3 | 3/3 | 3/5 | 7/8 | 4/4 | 25/29a | ||||
| ureA | 0/6 | 0/4 | 0/2 | 0/2 | 0/14 | |||||||
P = 0.024, compared with wild type (Fisher’s exact test).
