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Activity of 18 against Different P. falciparum Clones and Isolates
| P. falciparum IC50 (nM)a | ||||||
|---|---|---|---|---|---|---|
| Compd | NF54 | K1 | 7G8 | TM90C2B | RF12 | Dd2 |
| 18 | 41 ± 7.4 | 30 ± 7.5 | 32 ± 9.9 | 1,000 ± 84 | 11 ± 0.86 | 30 ± 7.2 |
| Chloroquine | 9.1 ± 1.5 | 270 ± 41 | 57 ± 0.9 | 160 ± 22 | 350 | 180 ± 21 |
| Artesunate | 6.0 ± 0.9 | 2.8 ± 0.64 | 2.3 ± 0.15 | 7.4 ± 1.3 | 6.8 ± 1.4 | 6.1 ± 1.4 |
Mean ± SD from n ≥ 2 independent experiments using the 72 h [3H] hypoxanthine incorporation assay.
