. Author manuscript; available in PMC: 2024 Oct 13.

Published in final edited form as: ACS Infect Dis. 2023 Sep 11;9(10):1964–1980. doi: 10.1021/acsinfecdis.3c00245

Table 6.

In Vitro Apparent Degradation Half-Lives for 2, 28, and 32 in P. falciparum Activity Test Medium and Mouse Blood


	In Vitro Assay Medium		Mouse Blood
Compd	Apparent degradation t_1/2 (h)^a	Corresponding 4(1H)-quinolone detected	Apparent degradation t_1/2 (h)^a	Corresponding 4(1H)-quinolone detected
2	No loss detected over 6 h	3	5.9 (5.3–6.7)	3
28	4.7 (3.6–7.1)	39	1.9 (1.7–2.1)	39
32	25 (16–60)	38	3.9 (3.4–4.6)	38

Values in parentheses represent the 95% confidence intervals for the half-lives.