Table 5:
Appendicular Musculoskeletal Structures and Derivatives
| Appendicular Musculoskeletal Component | Lineage Markers | Mesodermal Lineage |
|---|---|---|
| Pre-Osseous Mesenchymal Condensate |
PRRX1
PDGFRa |
Lateral Plate |
| Chondral Template/Immature Chondrocytes |
SOX9
NKX3.2 HES1 COL2A1 ACAN |
Lateral Plate |
| Hypertrophic Chondrocytes |
COL10A1
RUNX2 VEGF NOTCH 1/2 IHH MMP13 |
Lateral Plate |
| Perichrondrium |
OSX
HES1 DLX5 WNT5A WNT11 |
Lateral Plate |
| Trabecular Bone (Osteoblasts) |
OCN
OPN COL1A1 |
Lateral Plate |
| Osteoclasts |
TRAP
Cathepsin K |
Lateral Plate |
| Articular Cartilage |
GDF5
GDF6 WNT9A TPPP3 |
Lateral Plate |
| Synovium | PRG4 | Lateral Plate |
| Tendon/Ligament |
SCX
MKX |
Lateral Plate |
| Enthesis |
SCX
SOX9 GDF5 |
Lateral Plate |
| Myotendinous Junction | COLXXII | Mixed |
| Muscle |
PAX3
MYF5 |
Paraxial |
| Muscle Satellite Cells |
PAX7
NOTCH |
Paraxial |