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. 2024 Jan 25;15(2):294–301. doi: 10.1021/acsmedchemlett.3c00557

Figure 2.

Figure 2

In vitro uptake of [18F]Gln-OSO2F (a), [18F]Arg-OSO2F (b), and [18F]FSY-OSO2F (c) in MCF-7 cells in the presence and absence of competitive inhibitors of amino acid transporter. MeAIB = 10 mM N-methyl α-aminoisobutyric acid (system A inhibitor); BCH = 10 mM 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (system L inhibitor); ASC = 3.3 mM each of l-Ala, l-Ser, and l-Cys. ASC2 = 10 mM l-γ-glutamyl-p-nitroanilide; Arg = 10 mM arginine; Lys = 10 mM lysine; RKH = l-Arg, l-Lys, l-His mixture (3.3 mM of each amino acid); Tyr = 10 mM tyrosine. The PBS control condition was compared to the MeAIB BCH, ASC, ASC2, Gln, Arg, Lys, and RKH (n.s., non-significant; *p < 0.05 and **p < 0.01) conditions using two-tailed t tests. (d) In vitro cell uptakes of [18F]Gln-OSO2F, [18F]Arg-OSO2F, and [18F]FSY-OSO2F in MCF-7 cells.