Table 2. Effect of N-Boc-Noscapine Analogues 6a–6v and 7a–7o on the Proliferation of Cancer Cellsa.
| compound | growth
inhibition (%) |
|||||
|---|---|---|---|---|---|---|
| NB4 | MOLM-13 | Jeko-1 | A549 | HeLa | U251 | |
| 6a | 4.36 | 36.79 | 11.97 | <5.00 | <5.00 | <5.00 |
| 6b | 23.32 | 43.61 | 20.77 | <5.00 | <5.00 | 32.15 |
| 6c | 9.21 | 11.66 | 13.35 | <5.00 | 14.94 | 12.29 |
| 6d | 4.77 | 48.35 | 20.38 | <5.00 | 22.96 | 13.15 |
| 6e | 7.48 | 44.86 | 15.64 | <5.00 | 24.72 | 29.75 |
| 6f | 21.17 | 62.85 | 22.28 | 14.67 | 17.47 | <5.00 |
| 6g | 22.11 | 54.78 | 14.92 | 17.74 | <5.00 | <5.00 |
| 6h | 30.12 | 49.74 | 17.63 | <5.00 | <5.00 | <5.00 |
| 6i | 23.18 | 52.46 | 7.92 | <5.00 | <5.00 | <5.00 |
| 6j | 29.69 | 48.11 | 15.71 | <5.00 | 8.57 | <5.00 |
| 6k | 37.34 | 58.12 | 22.67 | <5.00 | <5.00 | <5.00 |
| 6l | 63.14 | 58.97 | 47.97 | 10.57 | <5.00 | <5.00 |
| 6m | 13.77 | 43.23 | 12.89 | <5.00 | <5.00 | <5.00 |
| 6n | 42.50 | 61.53 | 43.94 | <5.00 | 8.57 | <5.00 |
| 6o | 60.52 | 79.83 | 74.32 | 56.96 | 62.73 | 37.14 |
| 6p | 29.92 | 43.46 | 14.00 | <5.00 | <5.00 | <5.00 |
| 6q | 28.93 | 48.19 | 10.64 | <5.00 | <5.00 | <5.00 |
| 6r | 27.20 | 30.35 | 23.26 | <5.00 | <5.00 | <5.00 |
| 6s | 31.49 | 36.01 | 25.55 | <5.00 | <5.00 | <5.00 |
| 6t | 6.64 | 31.05 | 12.10 | <5.00 | <5.00 | <5.00 |
| 6u | 21.93 | 46.87 | <5.00 | <5.00 | <5.00 | <5.00 |
| 6v | 14.05 | 46.33 | 19.91 | <5.00 | 16.15 | 19.10 |
| 7a | 7.63 | 19.49 | 6.87 | <5.00 | <5.00 | <5.00 |
| 7b | 13.53 | 40.43 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7c | 11.61 | 40.05 | 5.81 | <5.00 | <5.00 | <5.00 |
| 7d | 6.53 | 46.10 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7e | 29.57 | 47.65 | 7.49 | <5.00 | <5.00 | <5.00 |
| 7f | 15.00 | 48.58 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7g | <5.00 | 17.63 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7h | <5.00 | 39.43 | 10.32 | <5.00 | <5.00 | 20.54 |
| 7i | 20.76 | 51.29 | 6.68 | <5.00 | <5.00 | 12.00 |
| 7j | <5.00 | 29.27 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7k | 8.20 | 43.61 | <5.00 | <5.00 | <5.00 | <5.00 |
| 7l | 8.80 | 53.08 | 6.67 | <5.00 | <5.00 | <5.00 |
| 7m | 10.01 | 48.58 | 11.44 | <5.00 | <5.00 | <5.00 |
| 7n | 9.33 | 51.22 | 23.98 | <5.00 | 6.92 | <5.00 |
| 7o | 25.11 | 63.16 | 13.65 | <5.00 | <5.00 | <5.00 |
| 1 | 26.70 | 18.96 | <5.00 | <5.00 | <5.00 | <5.00 |
| 2 | 38.30 | 41.91 | 48.90 | 15.92 | 28.13 | <5.00 |
| gemcitinibine | 95.66 | 74.10 | 65.17 | 62.32 | 61.42 | 69.68 |
Inhibition rates were reported at a concentration of 10 μM.