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. 2024 Jan 5;15(2):230–238. doi: 10.1021/acsmedchemlett.3c00462

Table 2. Effect of N-Boc-Noscapine Analogues 6a–6v and 7a–7o on the Proliferation of Cancer Cellsa.

compound growth inhibition (%)
  NB4 MOLM-13 Jeko-1 A549 HeLa U251
6a 4.36 36.79 11.97 <5.00 <5.00 <5.00
6b 23.32 43.61 20.77 <5.00 <5.00 32.15
6c 9.21 11.66 13.35 <5.00 14.94 12.29
6d 4.77 48.35 20.38 <5.00 22.96 13.15
6e 7.48 44.86 15.64 <5.00 24.72 29.75
6f 21.17 62.85 22.28 14.67 17.47 <5.00
6g 22.11 54.78 14.92 17.74 <5.00 <5.00
6h 30.12 49.74 17.63 <5.00 <5.00 <5.00
6i 23.18 52.46 7.92 <5.00 <5.00 <5.00
6j 29.69 48.11 15.71 <5.00 8.57 <5.00
6k 37.34 58.12 22.67 <5.00 <5.00 <5.00
6l 63.14 58.97 47.97 10.57 <5.00 <5.00
6m 13.77 43.23 12.89 <5.00 <5.00 <5.00
6n 42.50 61.53 43.94 <5.00 8.57 <5.00
6o 60.52 79.83 74.32 56.96 62.73 37.14
6p 29.92 43.46 14.00 <5.00 <5.00 <5.00
6q 28.93 48.19 10.64 <5.00 <5.00 <5.00
6r 27.20 30.35 23.26 <5.00 <5.00 <5.00
6s 31.49 36.01 25.55 <5.00 <5.00 <5.00
6t 6.64 31.05 12.10 <5.00 <5.00 <5.00
6u 21.93 46.87 <5.00 <5.00 <5.00 <5.00
6v 14.05 46.33 19.91 <5.00 16.15 19.10
7a 7.63 19.49 6.87 <5.00 <5.00 <5.00
7b 13.53 40.43 <5.00 <5.00 <5.00 <5.00
7c 11.61 40.05 5.81 <5.00 <5.00 <5.00
7d 6.53 46.10 <5.00 <5.00 <5.00 <5.00
7e 29.57 47.65 7.49 <5.00 <5.00 <5.00
7f 15.00 48.58 <5.00 <5.00 <5.00 <5.00
7g <5.00 17.63 <5.00 <5.00 <5.00 <5.00
7h <5.00 39.43 10.32 <5.00 <5.00 20.54
7i 20.76 51.29 6.68 <5.00 <5.00 12.00
7j <5.00 29.27 <5.00 <5.00 <5.00 <5.00
7k 8.20 43.61 <5.00 <5.00 <5.00 <5.00
7l 8.80 53.08 6.67 <5.00 <5.00 <5.00
7m 10.01 48.58 11.44 <5.00 <5.00 <5.00
7n 9.33 51.22 23.98 <5.00 6.92 <5.00
7o 25.11 63.16 13.65 <5.00 <5.00 <5.00
1 26.70 18.96 <5.00 <5.00 <5.00 <5.00
2 38.30 41.91 48.90 15.92 28.13 <5.00
gemcitinibine 95.66 74.10 65.17 62.32 61.42 69.68
a

Inhibition rates were reported at a concentration of 10 μM.