Table 3. In Vitro and in Vivo PK Parameters for VU6067416 (19d)^a.

parameter	value
in vitro
CLhep ((mL/min)/kg)	5.6 (human); 58 (rat); 57 (mouse)
fu	0.12 (human); 0.13 (rat); 0.12 (mouse)
P-gp efflux ratio (PappA-B (10–6 cm/s))	1.3 (7.9)
rat PK cassette (iv, 0.2 mg/kg)
CLp ((mL/min)/kg)	34.2
Vss (L/kg)	6.33
t1/2 (h)	2.8
Kp (measured at 0.25 h)	5.4

^aSee Supporting Information for additional experimental information.