. 2024 Jan 9;15(2):189–196. doi: 10.1021/acsmedchemlett.3c00456

Table 1. Modification at the R₁, R₂ and R₃ Positions and Effects on TLR7 Activity, Metabolic Stability, CYP, and hERG Inhibition^a.

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*The CYP inhibition panel included eight isoforms and the most potent IC₅₀ values are shown.

Table 1. Modification at the R1, R2 and R3 Positions and Effects on TLR7 Activity, Metabolic Stability, CYP, and hERG Inhibitiona.