Table 2. Evaluation of the Antibacterial Activity of Lipoguanidines.

compd	MIC (μg/mL)
	Gram-positive							Gram-negative
	S. aureus				E. faecalis		E. faecium	K. pneumoniae		A. baumannii		P. aeruginosa		E. coli
	MSSA ATCC 9144	MRSA NCTC 13616	MRSA USA 300	MRSA SA 1199B	VSE NCTC 775	VRE NCTC 12201	VRE NCTC 12204	NCTC 13368	M6	AYE	ATCC 17978	PAO1	NCTC 13437	NCTC 12923
5a	4	4	2	4	4	4	4	128	8	16	8	128	>128	8
5b	4	4	2	4	4–8	2	4	32–128	>128	32	8–16	>128	>128	16
5c	8	16	8	16	32	16	16	16	8	8	8	16	>64	4
5d	2–4	4	2–4	4	8	4	4	32	16	16	8	>128	>128	8
5e	8	8	4	8	8	8	8	>128	128	128	128	>128	>128	32
5f	128	>128	128	>128	>128	>128	>128	>128	>128	>128	>128	>128	>128	128
5g	16	32	32	32	128	>128	>128	>128	>128	>128	>128	>128	>128	128
5h	2	4	4	4	8	16	16	>128	>128	>128	128	>128	64	16
5i	2	2–4	2	4	2	2	2	>128	8–64	32→128	4–8	>128	>128	32–64
5j	8	4	2	4	2	2	2	>128	>128	128	16–32	>128	>128	>128
6	64	>64	64	32–64	64	>64	32	>128	>128	>128	128	>128	>128	128
8a	4	2	2	2	2	2	2	128	16	32	8	128	>128	8
8b	4–8	4–8	2–4	4–8	4–8	4	4	128	64	16–64	16	>128	>128	32
8c	4	4	4	4	8	8	8	>64	32	>64	32	64	64	8
8d	2–4	4	2	2–4	4	4	2	32–64	16–32	16–64	4–8	>128	>128	8
8e	NDa	NDa	NDa	NDa	NDa	NDa	NDa	>128	>128	>128	>128	64	>128	64
8f	128	>128	128	>128	>128	>128	>128	>128	>128	>128	>128	>128	>128	>128
10	8	4	4	4	4	4	4	>128	>128	128	64	64	32–64	8–16
agmatine	NDa	NDa	NDa	NDa	NDa	NDa	NDa	>128	>128	>128	>128	>128	>128	>128

^aNot determined.