Fig. 2.

The schematic features in each function module of CellNetdb. A The scatterplot represents the UMAP projection of different cell types. The hexbin scatterplot depicts the expression level of EPCAM that is a marker gene of epithelial cells. The circle plots show the cell–cell communication between different cell types. Additionally, the number of cells and marker genes for each cell type were described in a tabular form. B The graph plot depicts the local network connected to MDK gene queried from malignant epithelial cell-specific interactome networks in lung adenocarcinoma. The expression levels of all genes implicated in the local network are shown in the dot-plot heatmap where the color intensity represents the average expression level, and the size of dot represents the percentage of cells. C The somatic mutation spectra of each gene implicated in the local network of MDK is described in a table. D, E GO terms (D) and disease gene sets (E) enriched for the local network of MDK. The bar plots depict the enrichment P-values. Those genes of the corresponding GO term (D) or disease (E) implicated in the local network are labeled in purple. F The Kaplan–Meier curve depicts the difference between low- and high-expression level of SLC2A1 in TCGA lung adenocarcinoma (LUAD) cohort. The log-rank test P-value and univariate cox regression hazard ratio are labeled. SLC2A1 is implicated in the local network of MDK. G The circle plot shows the cell–cell communication between different cell types mediated by the MDK-LRP1 ligand-receptor pair in lung adenocarcinoma. The line weights represent the strengths of cell–cell communications