Table 1.
Mendelian randomization (MR) analysis of DM2 and BMD.
| Method | TB-BMD | FN-BMD | UF-BMD | H-BMD | LS-BMD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP (n) | OR (95%CI) |
P
Value |
SNP (n) | OR (95%CI) | p Value | SNP (n) | OR (95%CI) |
p
Value |
SNP (n) | OR (95%CI) |
p
Value |
SNP (n) | OR (95%CI) |
p
Value |
||
| DM2 | IVW | 118 |
1.03 (1.01,1.06) |
0.002 | 82 |
1.04 (1.01,1.07) |
0.001 | 115 |
1.05 (1.01,1.09) |
7e− 4 | 118 |
1.03 (1.01,1.06) |
4.3e− 4 | 82 |
1.05 (1.01,1.09) |
0.003 |
| MR Egger | 118 |
1.02 (0.97,1.08) |
0.33 | 82 |
1.05 (0.98,1.11) |
0.12 | 115 |
1.03 (0.95,1.13) |
0.38 | 118 |
1.01 (0.97,1.06) |
0.48 | 82 |
0.98 (0.92,1.06) |
0.73 | |
| Weighted median | 118 |
1.05 (1.02,1.09) |
0.0004 | 82 |
1.04 (0.99,1.09) |
0.08 | 115 |
1.06 (0.99,1.12) |
0.06 | 118 |
1.03 (1.01,1.05) |
9.48e− 10 | 82 |
1.00 (0.95,1.05) |
0.97 | |
| Weighted mode | 118 |
1.05 (1.01,1.09) |
0.01 | 82 |
1.05 (1,1.1) |
0.03 | 115 |
1.06 (0.99,1.14) |
0.08 | 118 |
1.03 (1.02,1.04) |
7.29e− 6 | 82 |
0.98 (0.92,1.04) |
0.51 | |
Note: DM2 Type 2 Diabetes Mellitus, MR Mendelian randomization, SNP single nucleotide polymorphism, TB Total body, FN, Femoral neck, UF, Ultradistal forearm, LS, Lumbar spine, BMD Bone mineral density, IVW inverse variance weighting, OR odds ratio, CI confidence interval