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. 2024 Jan 29;17:1240372. doi: 10.3389/fnins.2023.1240372

Figure 1.

Figure 1

The efficacy of PS in the treatment of CIPN mechanical allodynia. (A) Three groups of mice were treated with paclitaxel and one with its solvent control (n = 6-8/group) for 7 days as in Methods for the induction of CIPN. Treatment of two of the first three groups with PS or vehicle gel applied to the hind paws 3×/d × 16 d started on day 0. Mechanical allodynia was determined manually with the von Frey test at the indicated time points and was expressed as the paw withdrawal threshold (PWT) measured in grams. †p < 0.05, ‡p < 0.01, &p < 0.001, *p < 0.0001. Mixed Model results: Group (F(3, 3) = 50.8, p < 0.005); Time (F(5, 105) = 47.7, p < 0.0001); Group*Time (F(15, 15) = 7.8, p = 0.0001). (B) A similar study was performed using vincristine to induce CIPN. Mixed Model results: Group (F(3, 52) = 9.04, p < 0.0001); Time (F(2, 104) = 40.2, p < 0.0001); Group*Time (F(6, 104) = 7.82, p = 0.0001). At day 16, the difference in mechanical allodynia scores between PS and its vehicle control is highly significant. *p < 0.0001, n = 7. (C) Two groups of mice (n = 8/group) were treated with PS or vehicle as above for 22 days after the induction of CIPN by oxaliplatin (days-15 to 0). Mixed Model results: Group (F(1, 8) = 3.94, p = 0.0825); Time (F(4, 32) = 44.19, p < 0.0001); Group*Time (F(4, 32) = 3.13, p = 0.05). The mechanical allodynia score at D22 for PS treated mice is more toward normal untreated baseline and significantly different from vehicle treated mice. *p < 0.001, n = 5. All values: mean ± SEM.