Figure 3.

PS prevents CIPN mechanical allodynia. Three groups of mice were treated with paclitaxel and one with its solvent control (n = 8/group) for 8 days as in Methods for the induction of CIPN. Two of the paclitaxel treated groups had either PS gel or vehicle gel applied to their hind paws (3×/d × 10 d) beginning two days prior to the first injection of paclitaxel. Mechanical allodynia was determined manually with the von Frey test on day 10 (prior to euthanasia) and expressed as the PWT as measured in g. One-way ANOVA Results: Group (F(3, 21) = 39.87, p < 0.0001). *p < 0.0001, n = 6 to 7 mice per group.