Figure 5.

The efficacy of PS on allodynia during chemotherapy. (A) Mice with murine Lewis lung cancer (LL/2) subcutaneous xenografts (n = 8-10/group) were treated as shown for 7 days starting when the tumors reached ~180 mm³. Tumor size was measured at days 6 and 16 (end of study) of PS or vehicle treatment. Mixed Model results: Group (F(3, 29) = 13.34, p < 0.0001); Time (F(2, 58) = 258.14, p < 0.0001); Group*Time (F(6, 58) = 9.03, p = 0.0001). *p < 0.001 and **p < 0.0001compare tumor volume between paclitaxel treated mice verses paclitaxel control (receiving saline injections). n = 8–9 mice/group. (B). Mechanical allodynia was determined manually with the von Frey test on day 7 and was expressed as the PWT measured in g. One-way ANOVA Results: Group (F(3, 29) = 5.04, p < 0.05).*p < 0.025, **p < 0.01, n = 8–9 mice/group.