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. 2024 Jan 29;17:1240372. doi: 10.3389/fnins.2023.1240372

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Copyright © 2024 Basu, Yang, Tsirukis, Loiacono, Koch, Khwaja, Krishnamurthy, Fazio, White, Jha, Shah, Takmil, Bagdas, Demirer, Master, Natke, Honkanen, Huang and Rigas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PS reverses paclitaxel induced macrophage activation. Upper panel: RAW 264.7 macrophages (M0; left) were activated after a 24-h treatment with LPS 1 μg/mL and IFN-γ 40 ng/mL (middle and left), incubated in control media, and photographed on day 4. Lower panel: RAW 264.7 macrophages activated as above, were treated on day 3 with PS (left) or paclitaxel (center) or both (right) and photographed on day 4. All photographs were obtained with inverted light microscopy under phase contrast. Magnification: 20X for all except for 40X in the third picture in the upper panel. Scale bars = 50 μm.