Figure 8.

The efficacy of PS enantiomers in the treatment of CIPN mechanical allodynia. (A) The S atom of PS (the sulindac moiety in the box) is a chiral center. (B) Its two enantiomers were separated by supercritical fluid chromatography. (C) CIPN was induced in four groups of mice (n = 8/group) with paclitaxel as in Methods. When CIPN was established, mice were treated with either enantiomer, racemic PS (each as 5% gel) or vehicle, applied to the hind paws as above for 12 days. Mechanical allodynia was determined manually with the von Frey test and expressed as PWT measured in g. Mixed Model results: Group (F(3, 28) = 3.64, p < 0.025); Time (F(2, 56) = 43.96, p < 0.0001); Group*Time (F(6, 56) = 2.03, p = 0.077). Values: mean ± SEM. *p < 0.005 vs. vehicle.