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. 2024 Feb 8;16(1):2310603. doi: 10.1080/19490976.2024.2310603

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — A single-dose injection of (S)-ketamine does not ameliorate spatial working memory impairment in CCI mice. a: flowchart and timeline of the experiments. b: the OFT was used to examine locomotor activity (one-way ANOVA: F (2,21) = 0.5423, p = 0.5893). c:PWT (Kruskal-Wallis test, H = 17.428, p = 0.0002). d: PWL (Kruskal-Wallis test, H = 15.58, p = 0.0004). e: schematic of the Y-maze shape. f: number of arm entries in the Y-maze (one-way ANOVA: F (2,21) = 3.410, p = 0.0522. g: spontaneous alternation in the Y-maze (Kruskal-Wallis test, H = 14.77, p = 0.0006). N = 8/group. *p < 0.05, **p < 0.01, ***p <.001. PWT, paw withdrawal threshold; PWL, paw withdrawal latency; OFT, open field test.