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. 2024 Feb 8;16(1):2310603. doi: 10.1080/19490976.2024.2310603

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — Correlations between the level of butyric acid, BDNF, or the percentage of spontaneous alternation in the Y-maze test, and the significantly differing relative abundance of bacteria at both the genus and species levels.

a: Correlation between sodium butyrate and percentage of spontaneous alternation in the Y-maze (r = 0.6648, p < 0.0001). b: Correlation between sodium butyrate and BDNF expression in the hippocampus (r = 0.3627, p = 0.0489). c: Correlation between sodium butyrate and HDAC2 expression in the hippocampus (r = 0.3907, p = 0.0328). d: Correlation between BDNF expression in the hippocampus and percentage of spontaneous alternation in the Y-maze (r = 0.3725, p = 0.0426). e: Correlation between HDAC2 expression in the hippocampus and percentage of spontaneous alternation in the Y-maze (r = 0.3716, p = 0.0432). f: Heat map showing the correlation coefficient between bacterial abundance that differs from other groups at the genus level and butyric acid, Y-maze, hippocampal BDNF, and HDAC2 levels (Spearman analysis r = 0.35, p < 0.05). g: Heat map showing the correlation coefficient between bacterial abundance that differs from other groups at the genus level and butyric acid, Y-maze, hippocampal BDNF, and HDAC2 levels. *p < 0.05; **p < 0.01; ***p < 0.001.