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. 2024 Feb 8;16(1):2310603. doi: 10.1080/19490976.2024.2310603

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — FMT from (S)-ketamine -treated CCI mice can ameliorate the working memory impairment, but not mechanical allodynia and thermal hyperalgesia in CCI mice. a: flow chart of fecal sample collection from the donor mice. b: the spontaneous alternation in Y-maze of the donor mice (one-way ANOVA: F _{(2, 27)} = 8.112, p = 0.0017). c: the protocol of the FMT experiment. d: OFT: (one-way ANOVA: F _{(3, 36)} = 0.1794, p = 0.9097). e: PWT: (one-way ANOVA: F _{(3, 36)} = 36.90, p < 0.0001). f: PWL: (one-way ANOVA: F _{(3, 36)} = 22.98, p < 0.0001). g: number of arm entries in Y-maze (one-way ANOVA: F _{(3, 36)} = 1.940, p = 0.1405). h: the spontaneous alternation in Y-maze (one-way ANOVA: F _{(3, 36)} = 9.594, p < 0.0001). i: BDNF levels in hippocampus (one-way ANOVA: F _{(3, 36)} = 4.410, p = 0.0097). j: HDAC2 levels in hippocampus (one-way ANOVA: F _{(3, 36)} = 1.124, p = 0.3522). N = 10/group. *p < 0.05; **p < 0.01; ***p < 0.001. FMT, fecal microbiota transplantation; FMT1, sham + saline-treated sham mice feces; FMT2, sham + saline-treated CCI mice’ feces; FMT3, CCI + saline-treated CCI mice feces; FMT4, CCI + (S)-ketamine-treated CCI mice feces.PWT, paw withdrawal threshold; PWL, paw withdrawal latency; OFT, open field test; CCI, chronic constriction injury.