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. 2024 Feb 8;16(1):2310603. doi: 10.1080/19490976.2024.2310603

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — NaB can ameliorate thermal hyperalgesia and working memory impairment, but not mechanical allodynia in CCI mice. a: protocol for the experiment. b: OFT (two-way ANOVA: interaction, F_{(1, 36)} = 1.558, p = 0.22; CCI, F_(1,36) = 0.1764, p = 0.6769; NaB, F_(1,36) = 3.672, p = 0.0633). c: PWT (two-way ANOVA: interaction, F_{(1, 36)} = 1.334, p = 0.2558; CCI, F_(1,36) = 74.81, p < 0.0001; NaB, F_(1,36) = 0.2134, p = 0.6469). d: PWL (two-way ANOVA: interaction, F_{(1, 36)} = 4.920, p = 0.033; CCI, F_(1,36) = 52.77, p < 0.0001; NaB, F_(1,36) = 4.92, p = 0.033). e. Number of arm entries in Y-maze (two-way ANOVA: interaction, F _{(1, 36)} = 3.312, p = 0.0771; CCI, F _(1,36) = 0.7431, p = 0.3944; NaB, F _(1,36) = 0.2294, p = 0.6349). f: spontaneous alternation in the Y-maze (two-way ANOVA: interaction, F _{(1, 36)} = 8.414, p = 0.0063; CCI, F_(1,36) = 0.8044, p = 0.3757; NaB, F_(1,36) = 0.005, p = 0.94). g: BDNF levels in hippocampus (two-way ANOVA: interaction, F_{(1, 36)} = 2.121, p = 0.1540; CCI, F_(1,36) = 1.248, p = 0.2714; NaB, F_(1,36) = 4.503, p = 0.0408). h: HDAC2 levels in hippocampus (two-way ANOVA: interaction, F_{(1, 36)} = 0.9466, p = 0.3371; CCI, F_(1,36) = 3.881, p = 0.0566; NaB, F_(1,36) = 5.593, p = 0.0235). N = 10/group. *p < 0.05; **p < 0.01; ***p < 0.001. PWT, paw withdrawal threshold; PWL, paw withdrawal latency; OFT, open field test; CCI, chronic constriction injury; NaB, sodium butyrate.