Figure 8.

BLA, but not vlOFC, inhibition significantly slowed action-based probabilistic reversal adjustment reflected in accuracy around reversals. Plotted is the probability of choosing the better option [P(correct)] around reversal. Rats were always tested on a deterministic schedule before a probabilistic one. Shown are deterministic (100/0) and probabilistic (90/10) reversal transitions, 100 trials before and after each reversal. Drug order was counterbalanced such that on R2 and R4 animals received VEH if they were administered CNO first on R1 and R3 and vice versa. Inhibition of BLA impaired the first probabilistic reversal learning as indicated by selectively poor performance on R3 reversal. OFC inhibition resulted in no impairment around these reversals. There was also no effect of CNO in the eGFP group.