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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: Nat Methods. 2023 Nov 16;21(1):37–40. doi: 10.1038/s41592-023-02082-9

Extended Data Figure 8. Performance of GMM-based refinement in datasets at lower resolution.

Extended Data Figure 8

(A-C) Refinement of a small subset of the GPCR dataset. (D-F) Refinement of a small subset of the SARS-COV2 dataset. (A, D) “Gold-standard” FSC curves of the reconstruction using voxel-based refinement (gray), global GMM-based refinement (yellow) and patch-by-patch refinement (pink). (B, E) Overall structure of the initial reconstruction and the final patch-by-patch refinement result, colored by local resolution. (C, F) Comparison of local features from the voxel-based, global GMM-based and patch-by-patch refinement.