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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: Nat Methods. 2023 Nov 16;21(1):37–40. doi: 10.1038/s41592-023-02082-9

Extended Data Figure 1. Workflow diagram for GMM-based particle orientation and conformation refinement.

Extended Data Figure 1

Each block represents one step of processing, and the arrows indicate the sequence of the processes. The right side, DNN-based heterogeneity analysis is optional and is only recommended when large scale movement is present in the system. The result of the DNN-based refinement focusing on one region can be treated as one patch and merged into the patch-by-patch refinement results from the main workflow.