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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: Nat Methods. 2023 Nov 16;21(1):37–40. doi: 10.1038/s41592-023-02082-9

Extended Data Figure 7. Diagram for the patch-by-patch refinement.

Extended Data Figure 7

(A) Input density maps and GMMs from the global orientation refinement. (B) Scatter plot of Gaussian coordinates, colored by clustering result. (C) Soft masks for each cluster. Each mask is a sphere covering all Gaussian coordinates of the corresponding cluster, with a soft falloff. (D) Focused refinement results using the soft masks, colored by local resolution. Note that the same refinement process is done independently for the even/odd subsets of particles using the corresponding half map/GMM as reference. (E) Masked out density from the individual focused refinement result. (F) Final composite map generated by weighted averaging.