FIG. 4.

Effect of protease inhibitors (PROT I) on the release of ISF. Macrophages (MφS) were stimulated with TxA and then washed and incubated for a further 2 h in the presence of protease inhibitors (trypsin inhibitor and PMSF). The inhibitors were maintained in the incubation medium throughout the experiment. The resulting supernatants (SUP.) were tested on rabbit ileum. The results represent the mean ± SEM of the number (n) of preparations tested. ∗, the P value for SUP. MφS + TxA versus the other two groups was determined by ANOVA (Bonferroni or Dunn method).