FIG. 6.

Influence of anti-IL-1α and/or anti-IL-1β antibodies on intestinal secretion induced by supernatants (SUP.) from macrophages (MφS) stimulated with TxA. Supernatants of macrophages stimulated with TxA were incubated with either anti-IL-1α or anti-IL-1β antibodies or a combination of both for 30 min. The supernatants, together with the respective antibodies, were subsequently tested on rabbit ileum. The results represent the mean ± SEM of the number (n) of preparations tested. ∗, the P value for SUP. MφS + TxA versus SUP. MφS + TxA + anti-IL-1β, SUP. MφS + TxA + anti-IL-1α/β, or the control was determined by ANOVA (Bonferroni or Dunn method). The P value for SUP. MφS + TxA versus SUP. MφS + TxA + anti-IL-1α was not significant (Bonferroni or Dunn method).