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. 2024 Feb 8;17:853–863. doi: 10.2147/JIR.S428305

Figure 4.

Figure 4

Attenuation of sepsis-induced myocardial cell apoptosis by XDJHT is partially mediated by suppression of the PI3K/AKT signaling pathway. (A) Apoptosis detected by TUNEL assay. (B-E) Immunohistochemical staining for Bax, Bcl2, PI3K and p-AKT in myocardial tissue. Scale bar: 50 μm. All values are presented as the mean ± SD; *P < 0.05 for LPS+NS vs control group, #p < 0.05 for LPS+XJDHT vs LPS+NS group.(F and G) Western blotting to determine levels of Bax,Bcl-2,PI3K and p-AKT after XJDHT treatment in myocardial tissue.*P < 0.05 LPS+NS vs control group; #P < 0.05 LPS+NS + XJDHT vs LPS group.