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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: J Autoimmun. 2022 Nov 17;137:102946. doi: 10.1016/j.jaut.2022.102946

Figure 3. Premature accumulation of mature activated T cells.

Figure 3.

(A) Staining of CD3+CD4+ normal and patient T cells for expression of CD45RO and CCR7 reveals accelerated age-dependent loss of naïve CD45RO- CCR7+ T cells, with accumulation of CD45RO+CCR7+ central memory and CD45RO+CCR7- effector memory cells. C = normal control subject, 20 years old; P364L-1 (P1), 18 years old; P364L-2 (P2), 12 years old; P364L-3 (P3), 4 years old. (B) Staining of CD3+CD8+ normal and patient T cells for expression of CD45RO and CCR7 reveals a loss of naïve CD8+ T cells. (C) Expansion of the CD3+CD4+CD127- CD25+ Treg compartment in P364L RelB patients.