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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: J Autoimmun. 2022 Nov 17;137:102946. doi: 10.1016/j.jaut.2022.102946

Figure 5. P364L RelB instability and TLR-mediated induction.

Figure 5.

(A) Brief treatment with MG132 or Lactocystin proteasomal inhibitors results in a rapid increase in P364L RelB protein expression in patient cells (left panel). In comparison, normal cells (C) demonstrate little change in RelB protein level (right panel). (B) LPS treatment up-regulates RelB protein expression in P364L RelB patient fibroblasts. (C) Removal of LPS after 24 hours, results in rapid loss of the induced P364L RelB protein to pre-stimulation levels. (D) Activation of TLR2 and TLR3 by Pam3CSK4 (Pam3) and poly(I:C), respectively, can also increase P364L RelB expression.