. 2023 Jun 20;88(13):8658–8668. doi: 10.1021/acs.joc.3c00558

Table 5. Alternative Methodologies (A or B) for the Conversion of Compounds 1a–d into Cyanamides 8a–d and Tetrazolyl Derivatives 9a–d.

entry	compound	R¹	R²	yield 8 (%)	yield 9 (%)^a
1	a	H	H	31	39
2	b	Me	Me	67	80
3	c	Me	H	41	81
4	d	Cl	Me	25^b	57

After isolation by column chromatography.

The cyanamide 8d was impurified with a 10% of starting material (1d).