Fig.1 |. Quantification of SV-MR spectra obtained in posterior cingulum with single-voxel proton-MRS.

Bar diagrams demonstrate concentration comparisons quantified from the first and last time-point spectra following ²H-Glc and ¹H-Glc administration for 5 healthy volunteers and reflect continuously decaying metabolite signals through the acquisition period. Peaks that originated from the specific carbon position undergoing deuteration, namely, the 6^th carbon position for Glc (Glc₆) the 4^th carbon position for Glu (Glu₄) and Gln (Gln₄) and the 2^nd carbon position for GABA (GABA₂), were separated. Concentrations were compared with a standard, two-tailed, paired t-test between the first and last time-point within the ²H-Glc and ¹H-Glc sessions. The metabolites that appeared significant (p < 0.05) are displayed here. The whiskers represent the minimal and maximal values, the boxes first and third quartile and the dashed lines are medians. P-values were not corrected for multiple comparisons. The full analyzed neurochemical profile is shown at Suppl. Fig.1.