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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: Nat Biomed Eng. 2023 Apr 27;7(8):1001–1013. doi: 10.1038/s41551-023-01035-z

Fig. 7 |. Voxel-wise fitting of Glu4 and Glx4 time-courses obtained with high time resolution.

Fig. 7 |

MRSI data were acquired in one participant with a time-resolution of five (1H-MRSI, panel A.) and 6 minutes (2H-MRSI, panel B.) after peroral administration of 2H-Glc. Maps demonstrate the signal decay of protons on the 4th carbon position in the glutamate molecule (Glu4, 1H-MRSI) and in Glx4 (2H-MRSI). Voxel-wise linear regression was applied to Glu4 and Glx4 time-courses. Respective slopes tend to be higher in the gray matter, which suggests a higher glutamate turnover in the gray than in the white matter. The p-values refer to the significance of the slopes. Spectral postprocessing of 1H-MRSI included channel-wise L2-regularization for suppression of unwanted lipid signals.