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. Author manuscript; available in PMC: 2024 Feb 12.
Published in final edited form as: Chem Res Toxicol. 2022 Jun 23;35(7):1267–1276. doi: 10.1021/acs.chemrestox.2c00110

Table 5.

Average Nicotine Degradation Factors (Levels of Degradation of +6 mg/mL nicotine/+flavorant) for Acetaldehyde, Acrolein, and Total Formaldehydea

average nicotine degradation factor (+6 mg/mL nicotine/+flavorant) ± standard deviation
no flavorantb benzaldehyde
(2.5 mg/mL)
vanillin
(31 mg/mL)
benzyl alcohol
(39 mg/mL)
trans-cinnamaldehyde
(39 mg/mL)
trans-cinnamaldehyde
(155 mg/mL)
“flavorant mixture”c
acetaldehyde 1.0 ± 0.1 0.7 ± 0.1 0.4 ± 0.1 0.8 ± 0.1     2.3 ± 0.8     2.9 ± 1.0 0.6 ± 0.2
acrolein 1.0 ± 0.1 0.8 ± 0.1 0.5 ± 0.2 0.8 ± 0.1     2.3 ± 0.9     2.9 ± 0.8 0.6 ± 0.2
total formaldehydea 1.0 ± 0.1 0.7 ± 0.1 0.5 ± 0.1 0.8 ± 0.2     NAd     NAd NAd
a

Formaldehyde + formaldehyde hemiacetal + total MAPs; total MAPs = 5.8 + 5.3 + 5.1 ppm multiple addition products.

b

The nicotine degradation factor was calculated by dividing the + 6 mg/mL nicotine by PG + GL.

c

Flavorant mixture = 0.025 mg/mL benzaldehyde; 7.75 mg/mL vanillin; 9.75 mg/mL benzyl alcohol; 39 mg/mL trans-cinnamaldehyde.

d

Not able to be analyzed due to peak overlap.