Figure 1.

Schematic representation of different EV subtypes and their origin. Different processes of EV generation are schematized, including EV released by budding of the plasma membrane (microvesicles, exopheres, and mitovesicles), by retraction fibers of migrating cells (migrasomes), or by membrane fusion of multivesicular bodies (exosomes). The intracellular steps of endosome maturation and multivesicular body formation and the release of small particles (exomeres and supermeres) are also shown. ILV, intraluminal vesicles; MVB, multivesicular body.